BIOGRAPHICAL SKETCH
Provide the following information for the Senior/key personnel and other significant contributors.
Follow this format for each person. DO NOT EXCEED FIVE PAGES.
NAME: Scott D. Cook-Sather, MD
eRA COMMONS USER NAME (credential, e.g., agency login): xxxxxxxxx
POSITION TITLE: Associate Professor of Anesthesiology and Critical Care Medicine
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable. Add/delete rows as necessary.)
INSTITUTION AND LOCATION DEGREE
(if applicable)
Completion Date
MM/YYYY
FIELD OF STUDY
Stanford University, Stanford, CA BS 06/1985 Chemistry
Stanford University, Stanford, CA MD 06/1990 Medicine
University of California at San Francisco, PA 06/1991 Internship, Medicine
University of Pennsylvania, Philadelphia, PA
Children’s Hospital of Philadelphia, PA 06/1994
06/1995 Residency, Anesthesiology
Fellowships in Pediatric and Pediatric Cardiac Anesthesia
A. Personal Statement
I am an Associate Professor of Anesthesiology and Critical Care Medicine at the University of Pennsylvania Perelman School of Medicine and faculty at the Children’s Hospital of Philadelphia (CHOP). For three decades I have been interested in, studied, and promoted best practices in Pediatric Anesthesiology, presenting at national and international levels and publishing in high impact journals. In recent years I have focused on pharmacogenomics in Anesthesiology.
B. Positions, Scientific Appointments, and Honors
2018-2024 Medical Director, Perioperative Services, CHOP, King of Prussia, PA
2006-present Associate Professor, Perelman School of Medicine at the University of Pennsylvania; CHOP, Philadelphia, PA
1997-2006 Assistant Professor Hospital of the University of Pennsylvania and CHOP, University of Pennsylvania School of Medicine, Philadelphia, PA
1995-1996 Lecturer in Anesthesiology, Hospital of the University of Pennsylvania and CHOP, University of Pennsylvania School of Medicine, Philadelphia, PA
C. Contributions to Science relevant to this application
1. Pharmacogenomics. With Drs. Jin Li and Hakon Hakonarson at the CHOP Center for Applied Genomics (CAG), I researched morphine analgesia and acute postoperative pain in children, using genome-wide association study (GWAS) methodology to discover a novel genetic locus, TAOK3, associated with morphine sensitivity.a This locus subsequently has been implicated in altering daily opioid requirements for adult palliative care patients (Gutteridge, 2018). We have worked to develop predictive models for postoperative pain based on TAOK3 and a series of candidate genes, showing distinct racial differences.b We collaborated with research teams from Yale and Penn to help discover a novel locus related to OPMR1 that influences methadone dosing in adults with substance use disorders.c Specifically, our pediatric day surgery patient database was used to validate the novel finding in the Yale/Penn discovery cohort. We have used the CHOP ARCUS database to identify children with adverse reactions to benzodiazepines and are currently conducting a GWAS on CAG samples for this phenotype.
a. Cook-Sather SD, Li J., Goebel TK, Sussman EM, Rehman MA, Hakonarson H: TAOK3, a novel genome-wide association study locus associated with morphine requirement and postoperative pain in a retrospective pediatric day surgery population. Pain 155(9): 1773-83, September 2014.
b. Li J, Wei Z, Zhang J, Hakonarson H, Cook-Sather SD: Candidate gene analyses for acute pain and morphine analgesia after pediatric day surgery: African American versus European Caucasian ancestry and dose prediction limits. Pharmacogenomics J 19(6): 570-581, December 2019.
c. Smith AH, Jensen KP, Li J, Nunez Y, Farrer LA, Hakonarson H, Cook-Sather SD, Kranzler HR, Gelernter J: Genome-wide association study of therapeutic opioid dosing identifies a novel locus upstream of OPRM1. Molecular Psychiatry 22(3): 346-352, March 2017.
2. Best practices in Pediatric Anesthesiology. Guidelines for best practice are, of course, nuanced by many specific patient factors. Our team studied those associated with acute postoperative pain and emergence delirium following bilateral myringotomy and pressure equalization tube placement (BMT) in children. We found that combination intraoperative fentanyl/ketorolac analgesic dosing constituted best practice and that factors such as age and preoperative midazolam administration were also associated with postoperative pain outcome.a In a group of patients managed with ketorolac as the sole intraoperative analgesic we discovered that middle ear condition at the time of BMT was strongly associated with acute postoperative pain.b Most recently, we determined that ear condition factors into postoperative pain risk even when combination fentanyl/ketorolac is used, although demonstrated seasonal variation in ear condition, significantly altered by the COVID-19 pandemic, did not translate to measurable variation in moderate to severe postoperative pain.c For these and other pediatric phenotype studies we have leveraged the large data sets required to elucidate influences of multiple factors (genetic or otherwise) each with small contributory effects.
a. Stricker PA, Muhly WT, Jantzen EC, Li Y, Jawad AF, Long AS, Polansky M, Cook-Sather SD: Intramuscular fentanyl and ketorolac associated with superior pain control after pediatric bilateral myringotomy and tube placement surgery: A retrospective cohort study. Anesthesia & Analgesia 124(1): 245-253, January 2017.
b. Cook-Sather SD, Castella G, Zhang B, Mensinger JL, Galvez J, Wetmore RF: Principal factors associated with ketorolac-refractory pain behavior after pediatric myringotomy and pressure equalization tube placement: A retrospective cohort study. Anesthesia & Analgesia 130(3): 730-739, March 2020.
c. Cohen WG, Zhang B, Lee D, Ampah SB, Sobol SE, Cook-Sather SD. Middle ear condition at the time of pediatric myringotomy tube placement: pain associations following intraoperative fentanyl/ketorolac and seasonal variation. Submitted to Anesthesia & Analgesia, 136(5): 975-985.